BAIT
FXN
CyaY, FA, FARR, FRDA, X25
frataxin
GO Process (16)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- cellular iron ion homeostasis [IMP]
- cellular response to hydrogen peroxide [IDA]
- heme biosynthetic process [NAS]
- iron incorporation into metallo-sulfur cluster [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of lyase activity [IDA, IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of oxidoreductase activity [IMP]
- positive regulation of transferase activity [IMP]
- protein autoprocessing [IDA]
- regulation of ferrochelatase activity [IDA]
- response to iron ion [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GRHPR
GLXR, GLYD, PH2, RP11-397D12.2
glyoxylate reductase/hydroxypyruvate reductase
GO Process (7)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex process vital in brain homeostasis and disease. Yet which MP assemblies remodel during differentiation remains unclear. Here, using mass spectrometry-based co-fractionation profiles and phosphoproteomics, we generated mitochondrial interaction maps of human pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which presented as two discrete cell populations by single-cell RNA ... [more]
iScience Sep. 27, 2019; 19();1114-1132 [Pubmed: 31536960]
Quantitative Score
- 1.575788022 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Protein pairs with Sigma LLS score >= 1.45 derived from Ntera2 embryonic carcinoma stem cells (ECSC)
Curated By
- BioGRID