NOTCH1
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IMP]
- Notch signaling pathway [IMP, TAS]
- aortic valve morphogenesis [IMP]
- arterial endothelial cell differentiation [ISS]
- atrioventricular valve morphogenesis [ISS]
- cardiac atrium morphogenesis [ISS]
- cardiac chamber formation [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac muscle tissue morphogenesis [ISS]
- cardiac right atrium morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cardiac ventricle morphogenesis [ISS]
- cell migration involved in endocardial cushion formation [ISS]
- cellular response to follicle-stimulating hormone stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- cilium morphogenesis [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- determination of left/right symmetry [ISS]
- endocardial cell differentiation [ISS]
- endocardial cushion morphogenesis [ISS]
- endocardium development [ISS]
- endocardium morphogenesis [ISS]
- epithelial to mesenchymal transition [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- gene expression [TAS]
- growth involved in heart morphogenesis [ISS]
- heart development [IMP]
- heart looping [ISS]
- heart trabecula morphogenesis [ISS]
- immune response [NAS]
- mesenchymal cell development [ISS]
- mitral valve formation [IMP]
- negative regulation of BMP signaling pathway [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of myoblast differentiation [IMP]
- negative regulation of myotube differentiation [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of pro-B cell differentiation [ISS]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- neuronal stem cell maintenance [IEP]
- pericardium morphogenesis [ISS]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISS]
- positive regulation of transcription of Notch receptor target [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- pulmonary valve morphogenesis [IMP]
- regulation of extracellular matrix assembly [ISS]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISS]
- regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- tube formation [IMP]
- vasculogenesis involved in coronary vascular morphogenesis [ISS]
- venous endothelial cell differentiation [ISS]
- ventricular septum morphogenesis [IMP]
- ventricular trabecula myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DTX1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- negative regulation of neuron differentiation [IGI]
- regulation of Notch signaling pathway [IGI]
- regulation of nucleic acid-templated transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.
Intercellular signaling through the cell-surface receptor Notch plays important roles in a variety of developmental processes as well as in pathogenesis of some human cancers and genetic disorders. However, the mechanisms by which Notch signals are transduced into cells still remain elusive. Here we investigated the signaling mechanisms for Notch in the cell fate control of neural progenitor cells. We ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DTX1 NOTCH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DTX1 NOTCH1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - | |
| NOTCH1 DTX1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID