CITED2
Gene Ontology Biological Process
- adrenal cortex formation [ISS]
- cell proliferation [IDA]
- determination of left/right symmetry [ISS]
- embryonic heart tube left/right pattern formation [ISS]
- heart development [IMP, ISS]
- left/right axis specification [ISS]
- liver development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISS]
- outflow tract morphogenesis [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell-cell adhesion [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of male gonad development [ISS]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- regulation of nucleic acid-templated transcription [IDA]
- regulation of organ formation [ISS]
- response to estrogen [IDA]
- response to fluid shear stress [IMP]
- response to hypoxia [IDA, IMP]
- sex determination [ISS]
- spleen development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
TFAP2C
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- male gonad development [IEP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell proliferation [IBA]
- regulation of gene expression, epigenetic [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- core promoter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- core promoter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.
Members of the CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) family bind CREB-binding protein and p300 with high affinity and regulate gene transcription. Gene knockout studies indicate that CITED2 is required for neural crest and neural tube development and that it functions as a co-activator for transcription factor AP-2 (TFAP2). Here we describe human CITED4, a new member of this ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CITED2 TFAP2C | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID