BAIT
CSNK2A2
CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
FGF2
BFGF, FGF-2, FGFB, HBGF-2
fibroblast growth factor 2 (basic)
GO Process (40)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.
Fibroblast growth factor-1 (FGF-1) has both extra- and intracellular functions. To identify intracellular binding partners for FGF-1, we isolated proteins from U2OS human osteosarcoma cells interacting specifically with FGF-1. One of the isolated proteins was identified as protein kinase CK2 (CK2). We here provide evidence that FGF-1 binds to both the catalytic alpha-subunit and to the regulatory beta-subunit of CK2. ... [more]
EMBO J. Aug. 01, 2002; 21(15);4058-69 [Pubmed: 12145206]
Throughput
- Low Throughput
Curated By
- BioGRID