BAIT
PSAP
GLBA, SAP1
prosaposin
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRDX5
ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, prx-V, SBBI10
peroxiredoxin 5
GO Process (12)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- NADPH oxidation [IDA]
- cellular response to reactive oxygen species [IMP]
- hydrogen peroxide catabolic process [IDA]
- inflammatory response [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- reactive nitrogen species metabolic process [IDA]
- regulation of apoptosis involved in tissue homeostasis [IDA]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function- RNA polymerase III regulatory region DNA binding [IDA]
- antioxidant activity [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- peroxidase activity [IDA]
- peroxiredoxin activity [IDA]
- peroxynitrite reductase activity [IDA]
- protein dimerization activity [IDA]
- receptor binding [IPI]
- RNA polymerase III regulatory region DNA binding [IDA]
- antioxidant activity [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- peroxidase activity [IDA]
- peroxiredoxin activity [IDA]
- peroxynitrite reductase activity [IDA]
- protein dimerization activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- peroxisomal matrix [IDA]
- peroxisome [IDA]
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex process vital in brain homeostasis and disease. Yet which MP assemblies remodel during differentiation remains unclear. Here, using mass spectrometry-based co-fractionation profiles and phosphoproteomics, we generated mitochondrial interaction maps of human pluripotent embryonal carcinoma stem cells and differentiated neuronal-like cells, which presented as two discrete cell populations by single-cell RNA ... [more]
iScience Sep. 27, 2019; 19();1114-1132 [Pubmed: 31536960]
Quantitative Score
- 1.549348124 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Protein pairs with Sigma LLS score >= 1.45 derived from NTera2 retinoic acid (RA)-induced differentiated neuronal-like cells (DNLCs)
Curated By
- BioGRID