BAIT
CLIC4
chloride intracellular channel 4
GO Process (12)
GO Function (3)
GO Component (20)
Gene Ontology Biological Process
- angiogenesis [ISO]
- branching morphogenesis of an epithelial tube [ISO]
- cellular response to calcium ion [ISO]
- chloride transmembrane transport [IDA]
- chloride transport [TAS]
- endothelial cell morphogenesis [ISO]
- fertilization [ISO]
- keratinocyte differentiation [ISO]
- multicellular organism growth [ISO]
- negative regulation of cell migration [ISO, ISS]
- retina vasculature morphogenesis in camera-type eye [ISO]
- vacuolar acidification [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISO]
- cell [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- centrosome [ISO]
- cytoplasm [ISO, ISS, TAS]
- cytosol [ISO]
- endoplasmic reticulum [TAS]
- extracellular vesicular exosome [ISO]
- integral component of membrane [TAS]
- intracellular [ISO]
- microtubule cytoskeleton [ISO]
- microvillus [ISO]
- midbody [ISO]
- mitochondrion [ISO]
- nuclear matrix [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- vacuole [ISO]
- vesicle [TAS]
Rattus norvegicus
PREY
YWHAE
14-3-3e
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GO Process (11)
GO Function (13)
GO Component (6)
Gene Ontology Biological Process
- cerebral cortex development [ISO]
- hippocampus development [ISO]
- negative regulation of peptidyl-serine dephosphorylation [ISO]
- negative regulation of protein dephosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [TAS]
- neuron migration [ISO]
- protein targeting [ISO]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- signal transduction [TAS]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- MHC class II protein complex binding [ISO]
- enzyme binding [IPI, ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase C inhibitor activity [TAS]
- MHC class II protein complex binding [ISO]
- enzyme binding [IPI, ISO]
- histone deacetylase binding [ISO]
- ion channel binding [ISO]
- phosphoprotein binding [ISO]
- phosphoserine binding [ISO]
- poly(A) RNA binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase C inhibitor activity [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms.
Mammalian chloride intracellular channel (CLIC) (p64-related) proteins are widely expressed, with an unusual dual localization as both soluble and integral membrane proteins. The molecular basis for their cellular localization and ion channel activity remains unclear. To help in addressing these problems, we identified novel rat brain CLIC4 (p64H1) binding partners by affinity chromatography, mass spectrometric analysis and microsequencing. Brain CLIC4 ... [more]
Biochem. J. Oct. 01, 2001; 359(0);55-64 [Pubmed: 11563969]
Throughput
- Low Throughput
Curated By
- BioGRID