BAIT
CPNE1
COPN1, CPN1, RP1-309K20.2
copine I
GO Process (2)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP5C
AU020526, PP5
protein phosphatase 5, catalytic subunit
GO Process (12)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dephosphorylation [IMP]
- histone dephosphorylation [ISO]
- negative regulation of cell death [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- protein dephosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein oligomerization [ISO]
- response to morphine [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
We provide evidence that copines, members of a ubiquitous family of calcium-dependent, membrane-binding proteins, may represent a universal transduction pathway for calcium signaling because we find copines are capable of interacting with a wide variety of "target" proteins including MEK1, protein phosphatase 5, and the CDC42-regulated kinase, that are themselves components of intracellular signaling pathways. The copine target proteins were ... [more]
J. Biol. Chem. Mar. 21, 2003; 278(12);10048-54 [Pubmed: 12522145]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PPP5C CPNE1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID