AATK
Gene Ontology Molecular Function
CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IDA]
- axon extension [TAS]
- axon guidance [ISO, ISS]
- axonal fasciculation [ISO, ISS]
- brain development [IEP, ISO, ISS]
- cerebellum development [ISO]
- cerebral cortex radially oriented cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- hippocampus development [ISO]
- ionotropic glutamate receptor signaling pathway [IDA]
- layer formation in cerebral cortex [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron cell-cell adhesion [ISO, ISS]
- neuron differentiation [IDA]
- neuron migration [ISO, ISS]
- neuron projection development [IMP]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [IDA, ISO]
- positive regulation of protein targeting to membrane [ISO]
- protein phosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISO]
- regulation of cell cycle [IDA]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of microtubule cytoskeleton organization [ISO]
- serine phosphorylation of STAT3 protein [ISO]
- superior olivary nucleus maturation [ISO]
Gene Ontology Molecular Function- cadherin binding [IDA]
- calcium ion binding [IDA]
- cyclin-dependent protein kinase 5 activator activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [IDA, ISO]
- cadherin binding [IDA]
- calcium ion binding [IDA]
- cyclin-dependent protein kinase 5 activator activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [IDA, ISO]
Gene Ontology Cellular Component
- axon [IDA]
- contractile fiber [IDA]
- cyclin-dependent protein kinase 5 holoenzyme complex [IDA, TAS]
- cytoplasm [IDA, ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- growth cone [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
A 3(')-terminal fragment of a splice variant of KIAA0641, a human homologue of apoptosis-associated tyrosine kinase (AATYK), was screened from human brain cDNA libraries by a yeast two-hybrid system using a Cdk5 activator p35 as a bait. The cloned cDNA encoded 477 amino acids, composed of internal 458 amino acids of KIAA0641 and 19 amino acids unique to this variant ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID