BAIT
AATK
AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP
apoptosis-associated tyrosine kinase
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
CDK5R1
Cdk5r, p35
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
GO Process (31)
GO Function (9)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IDA]
- axon extension [TAS]
- axon guidance [ISO, ISS]
- axonal fasciculation [ISO, ISS]
- brain development [IEP, ISO, ISS]
- cerebellum development [ISO]
- cerebral cortex radially oriented cell migration [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- hippocampus development [ISO]
- ionotropic glutamate receptor signaling pathway [IDA]
- layer formation in cerebral cortex [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron cell-cell adhesion [ISO, ISS]
- neuron differentiation [IDA]
- neuron migration [ISO, ISS]
- neuron projection development [IMP]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [IDA, ISO]
- positive regulation of protein targeting to membrane [ISO]
- protein phosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISO]
- regulation of cell cycle [IDA]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of microtubule cytoskeleton organization [ISO]
- serine phosphorylation of STAT3 protein [ISO]
- superior olivary nucleus maturation [ISO]
Gene Ontology Molecular Function- cadherin binding [IDA]
- calcium ion binding [IDA]
- cyclin-dependent protein kinase 5 activator activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [IDA, ISO]
- cadherin binding [IDA]
- calcium ion binding [IDA]
- cyclin-dependent protein kinase 5 activator activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [IDA, ISO]
Gene Ontology Cellular Component
- axon [IDA]
- contractile fiber [IDA]
- cyclin-dependent protein kinase 5 holoenzyme complex [IDA, TAS]
- cytoplasm [IDA, ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- growth cone [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
A 3(')-terminal fragment of a splice variant of KIAA0641, a human homologue of apoptosis-associated tyrosine kinase (AATYK), was screened from human brain cDNA libraries by a yeast two-hybrid system using a Cdk5 activator p35 as a bait. The cloned cDNA encoded 477 amino acids, composed of internal 458 amino acids of KIAA0641 and 19 amino acids unique to this variant ... [more]
Biochem. Biophys. Res. Commun. Oct. 17, 2003; 310(2);398-404 [Pubmed: 14521924]
Throughput
- Low Throughput
Curated By
- BioGRID