BAIT
TADA2A
ADA2, ADA2A, TADA2L, hADA2, KL04P
transcriptional adaptor 2A
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NR3C1
GCCR, GCR, GCRST, GR, GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors.
In this work, we determined how altered-function mutants affecting hydrophobic residues within the tau 1-core activation domain of the human glucocorticoid receptor (GR) influence its physical interaction with different target proteins of the transcriptional machinery. Screening of putative target proteins showed that the tau 1-core can interact with the C-terminal part of the CREB-binding protein (CBP). In addition, the previously ... [more]
Biochemistry Jun. 30, 1998; 37(26);9586-94 [Pubmed: 9649342]
Throughput
- Low Throughput
Curated By
- BioGRID