MAP2K1
Gene Ontology Biological Process
- Golgi inheritance [ISO]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IMP, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [IMP]
- cell proliferation [ISO]
- cellular senescence [ISO]
- keratinocyte differentiation [IMP]
- labyrinthine layer development [IMP]
- melanosome transport [ISO]
- mitotic nuclear division [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [ISO]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [ISO]
- peptidyl-tyrosine dephosphorylation [IMP]
- placenta blood vessel development [IMP]
- positive regulation of Ras GTPase activity [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of cell differentiation [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [ISO]
- response to axon injury [ISO]
- response to glucocorticoid [ISO]
- response to oxidative stress [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase kinase activity [IMP, ISO]
- Ras GTPase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [IMP]
- ATP binding [ISO]
- MAP kinase kinase activity [IMP, ISO]
- Ras GTPase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, TAS]
- axon [ISO]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [ISO, TAS]
- dendrite [ISO]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [ISO]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
CPNE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
We provide evidence that copines, members of a ubiquitous family of calcium-dependent, membrane-binding proteins, may represent a universal transduction pathway for calcium signaling because we find copines are capable of interacting with a wide variety of "target" proteins including MEK1, protein phosphatase 5, and the CDC42-regulated kinase, that are themselves components of intracellular signaling pathways. The copine target proteins were ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID