Publication

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L

Despite the structural conservation of PTEN with dual-specificity phosphatases, there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity. Here, we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity. Mechanistically, high glucose, TGF-?, CTGF, SHH, and IL-6 induce the expression of ... [more]

Throughput

• High Throughput

Additional Notes

• hit proteins were identified by mass spectrometry in association with bait RNA

Curated By

• BioGRID