PTEN
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- activation of mitotic anaphase-promoting complex activity [IDA]
- apoptotic process [ISS]
- brain morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell migration [ISS]
- cell proliferation [TAS]
- central nervous system development [ISS]
- central nervous system myelin maintenance [ISS]
- central nervous system neuron axonogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- dentate gyrus development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- innate immune response [TAS]
- inositol phosphate dephosphorylation [IDA]
- inositol phosphate metabolic process [TAS]
- learning or memory [ISS]
- locomotor rhythm [ISS]
- locomotory behavior [ISS]
- multicellular organismal response to stress [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell size [ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- negative regulation of dendritic spine morphogenesis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of organ growth [ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [TAS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of synaptic vesicle clustering [ISS]
- neuron-neuron synaptic transmission [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of cell proliferation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- postsynaptic density assembly [ISS]
- prepulse inhibition [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [IDA, TAS]
- protein kinase B signaling [ISS]
- protein stabilization [IDA]
- regulation of cellular component size [ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of neuron projection development [ISS]
- regulation of protein stability [IMP]
- rhythmic synaptic transmission [ISS]
- small molecule metabolic process [TAS]
- social behavior [ISS]
- synapse assembly [ISS]
- synapse maturation [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
Gene Ontology Cellular Component
PARK7
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of protein kinase B activity [IC]
- cellular response to glyoxal [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA, IMP]
- glycolate biosynthetic process [IDA]
- glyoxal catabolic process [IDA]
- hydrogen peroxide metabolic process [IDA]
- lactate biosynthetic process [IDA]
- methylglyoxal catabolic process to D-lactate [IDA]
- mitochondrion organization [ISS]
- negative regulation of TRAIL-activated apoptotic signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell death [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- negative regulation of death-inducing signaling complex assembly [IC]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- negative regulation of hydrogen peroxide-induced neuron death [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of oxidative stress-induced cell death [IDA]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of protein K48-linked deubiquitination [IDA]
- negative regulation of protein acetylation [IDA]
- negative regulation of protein binding [IDA, IGI, IMP]
- negative regulation of protein export from nucleus [IGI]
- negative regulation of protein kinase activity [IGI]
- negative regulation of protein phosphorylation [IGI]
- negative regulation of protein sumoylation [IDA]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- negative regulation of ubiquitin-specific protease activity [IDA]
- positive regulation of L-dopa biosynthetic process [IMP]
- positive regulation of L-dopa decarboxylase activity [IDA]
- positive regulation of androgen receptor activity [IMP]
- positive regulation of dopamine biosynthetic process [IC, IDA]
- positive regulation of gene expression [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of protein kinase B signaling [IC]
- positive regulation of protein localization to nucleus [IDA, IMP]
- positive regulation of pyrroline-5-carboxylate reductase activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, TAS]
- positive regulation of superoxide dismutase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of tyrosine 3-monooxygenase activity [IDA]
- protein stabilization [IDA, IMP]
- regulation of TRAIL receptor biosynthetic process [IMP]
- regulation of androgen receptor signaling pathway [IDA]
- regulation of fibril organization [TAS]
- regulation of inflammatory response [ISS]
- regulation of mitochondrial membrane potential [IMP]
- regulation of neuron apoptotic process [IDA]
Gene Ontology Molecular Function- L-dopa decarboxylase activator activity [IDA]
- androgen receptor binding [IPI]
- core promoter binding [IC]
- cupric ion binding [IDA]
- cuprous ion binding [IDA]
- cytokine binding [IPI]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- glyoxalase (glycolic acid-forming) activity [IDA]
- glyoxalase III activity [IDA]
- identical protein binding [IPI]
- mRNA binding [IDA]
- oxidoreductase activity, acting on peroxide as acceptor [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- repressing transcription factor binding [IPI]
- scaffold protein binding [IPI]
- single-stranded DNA binding [IDA]
- small protein activating enzyme binding [IPI]
- small protein conjugating enzyme binding [IPI]
- superoxide dismutase copper chaperone activity [IDA]
- transcription coactivator activity [IGI, TAS]
- transcription factor binding [IPI]
- tyrosine 3-monooxygenase activator activity [IDA]
- ubiquitin-specific protease binding [IPI]
- L-dopa decarboxylase activator activity [IDA]
- androgen receptor binding [IPI]
- core promoter binding [IC]
- cupric ion binding [IDA]
- cuprous ion binding [IDA]
- cytokine binding [IPI]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- glyoxalase (glycolic acid-forming) activity [IDA]
- glyoxalase III activity [IDA]
- identical protein binding [IPI]
- mRNA binding [IDA]
- oxidoreductase activity, acting on peroxide as acceptor [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- repressing transcription factor binding [IPI]
- scaffold protein binding [IPI]
- single-stranded DNA binding [IDA]
- small protein activating enzyme binding [IPI]
- small protein conjugating enzyme binding [IPI]
- superoxide dismutase copper chaperone activity [IDA]
- transcription coactivator activity [IGI, TAS]
- transcription factor binding [IPI]
- tyrosine 3-monooxygenase activator activity [IDA]
- ubiquitin-specific protease binding [IPI]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.
Despite the structural conservation of PTEN with dual-specificity phosphatases, there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity. Here, we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity. Mechanistically, high glucose, TGF-?, CTGF, SHH, and IL-6 induce the expression of ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK7 PTEN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 728555 | |
| PTEN PARK7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 728556 | |
| PARK7 PTEN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 735966 | |
| PARK7 PTEN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PARK7 PTEN | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 735967 |
Curated By
- BioGRID