BAIT
LRRK2
4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
leucine-rich repeat kinase 2
GO Process (48)
GO Function (21)
GO Component (29)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- cellular response to dopamine [ISO]
- cellular response to manganese ion [ISO]
- cellular response to oxidative stress [ISO]
- determination of adult lifespan [ISO]
- endocytosis [ISO]
- exploration behavior [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of peroxidase activity [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of protein targeting to mitochondrion [ISO]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [ISO]
- neuromuscular junction development [ISO]
- neuron death [ISO]
- neuron projection morphogenesis [ISO]
- olfactory bulb development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of autophagy [IMP, ISO]
- positive regulation of dopamine receptor signaling pathway [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein autoubiquitination [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein autophosphorylation [ISA, ISO]
- protein phosphorylation [ISA, ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of branching morphogenesis of a nerve [ISO]
- regulation of dendritic spine morphogenesis [ISO]
- regulation of kidney size [IMP]
- regulation of locomotion [ISO]
- regulation of membrane potential [ISO]
- regulation of mitochondrial depolarization [ISO]
- regulation of neuroblast proliferation [ISO]
- regulation of neuron death [ISO]
- regulation of neuron maturation [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- response to oxidative stress [ISO]
- tangential migration from the subventricular zone to the olfactory bulb [ISO]
Gene Ontology Molecular Function- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISO]
- cytoplasm [ISO]
- cytoplasmic side of mitochondrial outer membrane [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [ISO]
- dendrite [ISO]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [IDA]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial matrix [IDA]
- mitochondrial membrane [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perikaryon [ISO]
- plasma membrane [IDA]
- synapse [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
Mus musculus
PREY
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Leucine-rich repeat kinase 2 (LRRK2) and tau have been identified as risk factors of Parkinson's disease (PD). As LRRK2 is a kinase and tau is hyperphosphorylated in some LRRK2 mutation carriers of PD patients, the obvious hypothesis is that tau could be a substrate of LRRK2. Previous reports that LRRK2 phosphorylates free tau or tubulin-associated tau provide direct support for ... [more]
Biochemistry Aug. 25, 2015; 54(33);5198-208 [Pubmed: 26268594]
Throughput
- Low Throughput
Curated By
- BioGRID