SQSTM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCG
Gene Ontology Biological Process
- chemosensory behavior [ISO]
- innervation [ISO]
- intracellular signal transduction [NAS]
- learning or memory [IEP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of proteasomal protein catabolic process [ISO, ISS]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein ubiquitination [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of mismatch repair [ISO]
- protein autophosphorylation [IDA]
- regulation of circadian rhythm [ISO, ISS]
- regulation of response to food [ISO, ISS]
- response to morphine [ISO, ISS]
- response to pain [ISO, ISS]
- synaptic transmission [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Protein Kinase C (PKC)? Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation.
PKM? is generated via an alternative transcriptional start site in the atypical protein kinase C (PKC)? isoform, which removes N-terminal regulatory elements, including the inhibitory pseudosubstrate domain, consequently rendering the kinase constitutively active. Persistent PKM? activity has been proposed as a molecular mechanism for the long-term maintenance of synaptic plasticity underlying some forms of memory. Many studies supporting a role ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID