SQSTM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCB
Gene Ontology Biological Process
- B cell activation [ISO, ISS]
- B cell receptor signaling pathway [ISO, ISS]
- calcium ion transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to carbohydrate stimulus [ISO]
- dibenzo-p-dioxin metabolic process [IEP]
- histone H3-T6 phosphorylation [ISO, ISS]
- intracellular signal transduction [NAS]
- negative regulation of glucose transport [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [IDA]
- positive regulation of B cell receptor signaling pathway [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of angiogenesis [ISO, ISS]
- positive regulation of odontogenesis of dentin-containing tooth [IEP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of dopamine secretion [IMP]
- regulation of growth [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- response to drug [IMP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hypoxia [ISO]
- response to vitamin D [IEP]
Gene Ontology Molecular Function- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Protein Kinase C (PKC)? Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation.
PKM? is generated via an alternative transcriptional start site in the atypical protein kinase C (PKC)? isoform, which removes N-terminal regulatory elements, including the inhibitory pseudosubstrate domain, consequently rendering the kinase constitutively active. Persistent PKM? activity has been proposed as a molecular mechanism for the long-term maintenance of synaptic plasticity underlying some forms of memory. Many studies supporting a role ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID