BAIT
SQSTM1
Osi, ZIP, ZIP3
sequestosome 1
GO Process (7)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PRKCE
Pkce
protein kinase C, epsilon
GO Process (32)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [ISO, ISS]
- cellular response to ethanol [ISO]
- cellular response to hypoxia [ISO]
- intracellular signal transduction [IDA]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- locomotory exploration behavior [ISO]
- macrophage activation involved in immune response [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitochondrial calcium ion concentration [IMP]
- negative regulation of mitochondrial membrane potential [IMP]
- negative regulation of release of sequestered calcium ion into cytosol [IMP]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of epithelial cell migration [ISO, ISS]
- positive regulation of fibroblast migration [ISO, ISS]
- positive regulation of insulin secretion [ISO]
- positive regulation of lipid catabolic process [ISO]
- positive regulation of mucus secretion [ISO]
- positive regulation of receptor activity [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of wound healing [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- regulation of lipid metabolic process [ISO]
- regulation of peptidyl-tyrosine phosphorylation [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to morphine [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein Kinase C (PKC)? Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation.
PKM? is generated via an alternative transcriptional start site in the atypical protein kinase C (PKC)? isoform, which removes N-terminal regulatory elements, including the inhibitory pseudosubstrate domain, consequently rendering the kinase constitutively active. Persistent PKM? activity has been proposed as a molecular mechanism for the long-term maintenance of synaptic plasticity underlying some forms of memory. Many studies supporting a role ... [more]
Mol. Pharmacol. Oct. 01, 2015; 88(4);728-35 [Pubmed: 26199377]
Throughput
- Low Throughput
Curated By
- BioGRID