SQSTM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCI
Gene Ontology Biological Process
- Golgi vesicle budding [IDA]
- actin filament organization [ISO]
- cell migration [IMP]
- cell-cell junction organization [ISO]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP, ISO]
- establishment of apical/basal cell polarity [ISO]
- eye photoreceptor cell development [ISO]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of endothelial cell apoptotic process [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of glial cell proliferation [ISO, ISS]
- positive regulation of glucose import [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- response to interleukin-1 [IMP]
- response to peptide hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- Schmidt-Lanterman incisure [ISO]
- apical part of cell [ISO]
- apical plasma membrane [ISO]
- cell leading edge [IDA]
- cytoplasm [ISO]
- cytosol [IDA, ISO, ISS]
- extracellular vesicular exosome [ISO]
- intercellular bridge [ISO]
- microtubule cytoskeleton [ISO]
- nucleus [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
- tight junction [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein Kinase C (PKC)? Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation.
PKM? is generated via an alternative transcriptional start site in the atypical protein kinase C (PKC)? isoform, which removes N-terminal regulatory elements, including the inhibitory pseudosubstrate domain, consequently rendering the kinase constitutively active. Persistent PKM? activity has been proposed as a molecular mechanism for the long-term maintenance of synaptic plasticity underlying some forms of memory. Many studies supporting a role ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SQSTM1 PRKCI | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID