BAIT
TIA1
2310050N03Rik, AI256674, TIA-1, mTIA-1
cytotoxic granule-associated RNA binding protein 1
GO Process (3)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PURA
CAGER-1, Pur-alpha, ssCRE-BP
purine rich element binding protein A
GO Process (9)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- DNA unwinding involved in DNA replication [ISO]
- apoptotic process [NAS]
- cell differentiation [NAS]
- cell proliferation [NAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- nervous system development [IMP]
- positive regulation of cell proliferation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.
Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates ... [more]
Cell Rep Dec. 17, 2015; 15(7);1455-1466 [Pubmed: 27160897]
Throughput
- High Throughput
Curated By
- BioGRID