BAIT
TIA1
2310050N03Rik, AI256674, TIA-1, mTIA-1
cytotoxic granule-associated RNA binding protein 1
GO Process (3)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
THY1
CD90, T25, Thy-1, Thy-1.2, Thy1.1, Thy1.2
thymus cell antigen 1, theta
GO Process (14)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- angiogenesis [IDA]
- cytoskeleton organization [ISO]
- focal adhesion assembly [ISO]
- negative regulation of T cell receptor signaling pathway [IDA]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of protein kinase activity [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- retinal cone cell development [IMP]
- single organismal cell-cell adhesion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [IDA]
- anchored component of plasma membrane [ISO]
- apical plasma membrane [ISO]
- cell surface [ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- membrane raft [IDA]
- myelin sheath [IDA]
- plasma membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.
Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates ... [more]
Cell Rep Dec. 17, 2015; 15(7);1455-1466 [Pubmed: 27160897]
Throughput
- High Throughput
Curated By
- BioGRID