BAIT
TIA1
2310050N03Rik, AI256674, TIA-1, mTIA-1
cytotoxic granule-associated RNA binding protein 1
GO Process (3)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GSTP1
GstpiB
glutathione S-transferase, pi 1
GO Process (22)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IDA]
- common myeloid progenitor cell proliferation [IMP]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of JUN kinase activity [IDA, IMP]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [IMP]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of neutrophil aggregation [NAS]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of peroxidase activity [IDA]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of stress-activated MAPK cascade [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.
Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates ... [more]
Cell Rep Dec. 17, 2015; 15(7);1455-1466 [Pubmed: 27160897]
Throughput
- High Throughput
Curated By
- BioGRID