BAIT
TIA1
2310050N03Rik, AI256674, TIA-1, mTIA-1
cytotoxic granule-associated RNA binding protein 1
GO Process (3)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PICALM
CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO]
- cell proliferation [ISO]
- clathrin coat assembly [ISO]
- clathrin-mediated endocytosis [ISO]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [IMP]
- iron ion homeostasis [ISO]
- iron ion import into cell [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- regulation of endocytosis [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [IDA, ISO]
- endosome [ISO]
- intracellular [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.
Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1. Analysis of the TIA1 interactome in brain tissue from wild-type (WT) and tau knockout mice demonstrates ... [more]
Cell Rep Dec. 17, 2015; 15(7);1455-1466 [Pubmed: 27160897]
Throughput
- High Throughput
Curated By
- BioGRID