BAIT
DYRK1A
DYRK, DYRK1, HP86, MNB, MNBH, MRD7
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
GO Process (9)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- circadian rhythm [ISS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- nervous system development [TAS]
- peptidyl-threonine phosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA, ISS]
- positive regulation of protein deacetylation [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
OPA1
MGM1, NPG, NTG, largeG
optic atrophy 1 (autosomal dominant)
GO Process (11)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- axon transport of mitochondrion [TAS]
- cellular senescence [IDA]
- inner mitochondrial membrane organization [IDA]
- mitochondrial fission [TAS]
- mitochondrial fusion [IDA, IMP, TAS]
- mitochondrial genome maintenance [IMP]
- mitochondrion organization [IMP, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.
Human Dual-specificity tyrosine (Y) Regulated Kinase 1A (DYRK1A) is encoded by a dosage dependent gene whereby either trisomy or haploinsufficiency result in developmental abnormalities. However, the function and regulation of this important protein kinase are not fully understood. Here, we report proteomic analysis of DYRK1A in human cells that revealed a novel role of DYRK1A in DNA double-strand breaks (DSBs) ... [more]
Cell Cycle Dec. 01, 2018; 18(5);531-551 [Pubmed: 30773093]
Throughput
- High Throughput
Additional Notes
- assayed using MudPIT (multidimensional protein identification technology)
Curated By
- BioGRID