APEX1
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, TAS]
- DNA catabolic process, exonucleolytic [IBA]
- DNA demethylation [IDA]
- DNA repair [IDA, TAS]
- base-excision repair [IBA, TAS]
- negative regulation of nucleic acid-templated transcription [TAS]
- oxidation-reduction process [IDA]
- positive regulation of DNA repair [IDA]
- regulation of mRNA stability [IMP]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IDA, TAS]
- DNA binding [IDA]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA, TAS]
- RNA-DNA hybrid ribonuclease activity [TAS]
- chromatin DNA binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IDA]
- metal ion binding [IDA]
- oxidoreductase activity [IDA]
- phosphodiesterase I activity [TAS]
- phosphoric diester hydrolase activity [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [TAS]
- uracil DNA N-glycosylase activity [TAS]
- 3'-5' exonuclease activity [IDA, TAS]
- DNA binding [IDA]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA, TAS]
- RNA-DNA hybrid ribonuclease activity [TAS]
- chromatin DNA binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IDA]
- metal ion binding [IDA]
- oxidoreductase activity [IDA]
- phosphodiesterase I activity [TAS]
- phosphoric diester hydrolase activity [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [TAS]
- uracil DNA N-glycosylase activity [TAS]
Gene Ontology Cellular Component
HDAC1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- chromatin modification [TAS]
- chromatin remodeling [IC]
- circadian regulation of gene expression [ISS]
- embryonic digit morphogenesis [ISS]
- epidermal cell differentiation [ISS]
- eyelid development in camera-type eye [ISS]
- fungiform papilla formation [ISS]
- gene expression [TAS]
- hair follicle placode formation [ISS]
- histone H3 deacetylation [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IMP]
- mitotic cell cycle [TAS]
- negative regulation by host of viral transcription [IMP]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell cycle [TAS]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis of dentin-containing tooth [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein deacetylation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- deacetylase activity [ISS]
- enzyme binding [IPI]
- histone deacetylase activity [IDA, IMP, TAS]
- histone deacetylase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- deacetylase activity [ISS]
- enzyme binding [IPI]
- histone deacetylase activity [IDA, IMP, TAS]
- histone deacetylase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC1 APEX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1054792 |
Curated By
- BioGRID