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BAIT

CTSD

CLN10, CPSD, HEL-S-130P

cathepsin D

Alzheimer's Disease Project

GO Process (4)

GO Function (1)

GO Component (6)

Gene Ontology Biological Process

antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]

collagen catabolic process [TAS]

extracellular matrix disassembly [TAS]

extracellular matrix organization [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular matrix [IDA]

extracellular region [NAS, TAS]

extracellular space [IDA, ISS]

extracellular vesicular exosome [IDA]

lysosomal lumen [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

MAPT

DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU

microtubule-associated protein tau

GO Process (8)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

apoptotic process [TAS]

cellular component disassembly involved in execution phase of apoptosis [TAS]

generation of neurons [NAS]

microtubule cytoskeleton organization [IDA]

positive regulation of axon extension [IDA]

positive regulation of microtubule polymerization [IDA]

regulation of autophagy [IGI]

regulation of microtubule polymerization [NAS]

Gene Ontology Molecular Function

SH3 domain binding [IPI]
apolipoprotein binding [IPI]
enzyme binding [IPI]
lipoprotein particle binding [IPI]
microtubule binding [IDA]
protein binding [IPI]
structural constituent of cytoskeleton [TAS]

Gene Ontology Cellular Component

cytoplasmic ribonucleoprotein granule [IDA]

growth cone [IDA]

microtubule associated complex [TAS]

nuclear periphery [IDA]

plasma membrane [IDA]

tubulin complex [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Biochemical Activity (Proteolytic Processing)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

Kenessey A, Nacharaju P, Ko LW, Yen SH

The degradation of different isoforms of human recombinant tau (R-tau; T39, T40, and T44) and fetal tau (F-tau) by cathepsin D (CD) was investigated. Gel electrophoresis and Coomassie Blue staining of different R-tau species digested at pH 3.5 showed very little differences in CD susceptibility. Immunoblotting analyses revealed that amino and carboxy termini of tau were cleaved before other regions. ... [more]

J. Neurochem. Nov. 01, 1997; 69(5);2026-38 [Pubmed: 9349548]

Throughput

Low Throughput

Curated By

BioGRID