RXRA
Gene Ontology Biological Process
- angiogenesis involved in coronary vascular morphogenesis [TAS]
- camera-type eye development [IGI]
- cardiac muscle cell differentiation [TAS]
- cardiac muscle cell proliferation [IGI, IMP, TAS]
- embryo implantation [IGI]
- heart development [IMP, TAS]
- heart morphogenesis [TAS]
- in utero embryonic development [IGI]
- maternal placenta development [IGI]
- mesenchyme development [TAS]
- modulation by virus of host morphology or physiology [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- peroxisome proliferator activated receptor signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- positive regulation of transcription, DNA-templated [IGI, TAS]
- positive regulation of translational initiation by iron [IGI]
- protein homotetramerization [ISO]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of myelination [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to glucocorticoid [ISO]
- response to retinoic acid [ISO]
- retinoic acid receptor signaling pathway [IDA, IMP, ISO]
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ventricular cardiac muscle cell differentiation [IGI, IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- visceral serous pericardium development [TAS]
Gene Ontology Molecular Function- 9-cis retinoic acid receptor activity [IDA]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- retinoic acid receptor binding [ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IGI, ISO]
- sequence-specific DNA binding transcription factor activity [IGI, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- vitamin D receptor binding [ISO]
- vitamin D response element binding [ISO]
- 9-cis retinoic acid receptor activity [IDA]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- retinoic acid receptor binding [ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IGI, ISO]
- sequence-specific DNA binding transcription factor activity [IGI, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- vitamin D receptor binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
TRAF6
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IMP]
- JNK cascade [ISO]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [IMP]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- bone remodeling [IMP]
- bone resorption [IMP]
- cell development [IMP]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO]
- immune response [IMP]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- osteoclast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of interleukin-12 biosynthetic process [IMP]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [IDA, ISO]
- protein autoubiquitination [ISO, TAS]
- protein complex assembly [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, IGI, IMP]
- regulation of immunoglobulin secretion [IDA]
- response to interleukin-1 [ISO]
- signal transduction [IDA, TAS]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Oncogenic potential of truncated RXR? during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling.
Retinoid X receptor-alpha (RXR?) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXR? is abnormally cleaved in tumor cells and tissues, producing a truncated RXR? (tRXR?). Here, we show that transgenic expression of tRXR? in mice accelerates the development of colitis-associated colon cancer (CAC). The tumorigenic ... [more]
Throughput
- Low Throughput
Additional Notes
- Interaction with tRXRA only
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRAF6 RXRA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 2634418 |
Curated By
- BioGRID