BAIT
STAT5A
Stat5
signal transducer and activator of transcription 5A
GO Process (61)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISO]
- JAK-STAT cascade [IDA, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISO]
- Peyer's patch development [ISO]
- T cell differentiation in thymus [ISO]
- T cell homeostasis [ISO]
- allantoin metabolic process [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- citrate metabolic process [ISO]
- creatine metabolic process [ISO]
- creatinine metabolic process [ISO]
- cytokine-mediated signaling pathway [ISO]
- development of secondary female sexual characteristics [ISO]
- development of secondary male sexual characteristics [ISO]
- epithelial cell differentiation involved in prostate gland development [ISO]
- fatty acid metabolic process [ISO]
- female pregnancy [ISO]
- isoleucine metabolic process [ISO]
- lactation [IEP, ISO]
- lipid storage [ISO]
- luteinization [ISO]
- mammary gland development [ISO]
- mammary gland epithelium development [ISO]
- mammary gland involution [IDA]
- multicellular organismal reproductive process [IEP]
- natural killer cell differentiation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of erythrocyte differentiation [ISO]
- negative regulation of mast cell apoptotic process [ISO]
- oxaloacetate metabolic process [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of B cell differentiation [ISO]
- positive regulation of activated T cell proliferation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gamma-delta T cell differentiation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interleukin-2 biosynthetic process [ISO]
- positive regulation of lymphocyte differentiation [ISO]
- positive regulation of mast cell differentiation [ISO]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of natural killer cell differentiation [ISO]
- positive regulation of natural killer cell mediated cytotoxicity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prolactin signaling pathway [ISO, ISS]
- prostate gland epithelium morphogenesis [ISO]
- regulation of cell adhesion [ISO]
- regulation of epithelial cell differentiation [ISO]
- regulation of multicellular organism growth [ISO]
- regulation of steroid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to ethanol [IEP]
- response to nutrient levels [IEP]
- response to peptide hormone [ISO]
- signal transduction [ISO]
- succinate metabolic process [ISO]
- taurine metabolic process [ISO]
- transcription from RNA polymerase II promoter [IDA]
- valine metabolic process [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- signal transducer activity [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- signal transducer activity [ISO]
Rattus norvegicus
PREY
OPRM1
MORA, Oprm, Oprrm1
opioid receptor, mu 1
GO Process (35)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- acute inflammatory response to antigenic stimulus [IEP]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA, ISO]
- adenylate cyclase-inhibiting opioid receptor signaling pathway [IDA]
- behavioral response to ethanol [ISO]
- calcium ion transmembrane transport [IMP]
- cellular response to morphine [IDA, IMP]
- immune response [TAS]
- locomotory behavior [ISO]
- negative regulation of Wnt protein secretion [ISO, ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP-mediated signaling [ISO, ISS]
- negative regulation of cytosolic calcium ion concentration [ISO, ISS]
- negative regulation of nitric oxide biosynthetic process [ISO, ISS]
- neuropeptide signaling pathway [IBA, ISO]
- opioid receptor signaling pathway [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of appetite [IMP]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of neurogenesis [ISO, ISS]
- positive regulation of nitric oxide biosynthetic process [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of sensory perception of pain [IDA]
- response to cocaine [IEP]
- response to ethanol [IDA]
- response to food [IEP]
- response to growth factor [IEP]
- response to lipopolysaccharide [IEP]
- response to morphine [IEP]
- sensory perception of pain [ISO, ISS]
- wound healing [IEP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor.
Signal Transducers and Activators of Transcription (STATs) are transcription factors shown to be activated by G protein-coupled receptors. In the present study, we demonstrate that acute morphine or [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO) exposure of COS-7 cells transiently transfected with the micro-opioid receptor and STAT5A, leads to receptor-dependent tyrosine phosphorylation of STAT5A. Activation of HEK293 cells, stably expressing the micro-opioid receptor with micro-opioid ... [more]
J. Neurochem. May. 01, 2005; 93(4);918-31 [Pubmed: 15857395]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPRM1 STAT5A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OPRM1 STAT5A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID