ELMO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
APBB1
Gene Ontology Biological Process
- axon guidance [ISO]
- cell cycle arrest [ISO, ISS]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [IMP, ISO]
- extracellular matrix organization [ISO]
- histone H4 acetylation [IMP]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of neuron differentiation [ISO]
- negative regulation of thymidylate synthase biosynthetic process [ISO, ISS]
- neuron migration [ISO]
- positive regulation of DNA repair [IMP, ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of protein secretion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [ISO, ISS]
- response to iron ion [IEP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Neurite outgrowth is a crucial process in developing neurons for neural network formation. Understanding the regulatory mechanisms of neurite outgrowth is essential for developing strategies to stimulate neurite regeneration after nerve injury and in neurodegenerative disorders. FE65 is a brain-enriched adaptor that stimulates Rac1-mediated neurite elongation. However, the precise mechanism by which FE65 promotes the process remains elusive. Here, we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID