APBB1
Gene Ontology Biological Process
- axonogenesis [NAS]
- cell cycle arrest [ISS]
- cellular response to DNA damage stimulus [IDA]
- histone H4 acetylation [ISS]
- negative regulation of cell growth [ISS]
- negative regulation of thymidylate synthase biosynthetic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ELMO1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rac protein signal transduction [IGI]
- actin cytoskeleton organization [IGI]
- apoptotic process [NAS]
- cellular component movement [IGI]
- innate immune response [TAS]
- phagocytosis, engulfment [IGI]
- regulation of defense response to virus by virus [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Neurite outgrowth is a crucial process in developing neurons for neural network formation. Understanding the regulatory mechanisms of neurite outgrowth is essential for developing strategies to stimulate neurite regeneration after nerve injury and in neurodegenerative disorders. FE65 is a brain-enriched adaptor that stimulates Rac1-mediated neurite elongation. However, the precise mechanism by which FE65 promotes the process remains elusive. Here, we ... [more]
Throughput
- Low Throughput
Additional Notes
- species of hit is unclear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APBB1 ELMO1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 2634472 |
Curated By
- BioGRID