BAIT
GRIN2C
GluN2C, NR2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GO Process (13)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- cation transmembrane transport [IDA, ISO]
- cation transport [IDA]
- directional locomotion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neuromuscular process controlling balance [ISO]
- protein localization [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of membrane potential [ISO]
- response to wounding [ISO]
- startle response [ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
DLG3
Dlgh3
discs, large homolog 3 (Drosophila)
GO Process (3)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- dendritic shaft [IDA]
- extracellular space [ISO]
- growth cone [IDA]
- neuronal cell body [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA, TAS]
- synapse [IDA]
- tight junction [ISO]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation.
NR2C-containing N-methyl-D-aspartate (NMDA) receptors are highly expressed in cerebellar granule cells where they mediate the majority of current in the adult. NMDA receptors composed of NR1/NR2C exhibit a low conductance and reduced sensitivity to Mg(2+), compared with the more commonly studied NR2A- and NR2B-containing receptors. Despite these interesting features, very little is known about the regulation of NR2C function. Here ... [more]
J. Biol. Chem. Jun. 16, 2006; 281(24);16583-90 [Pubmed: 16606616]
Throughput
- Low Throughput
Curated By
- BioGRID