BAIT
GPC4
K-glypican, RP6-198C21.1
glypican 4
GO Process (10)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- carbohydrate metabolic process [TAS]
- cell proliferation [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
PTPRD
HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA
protein tyrosine phosphatase, receptor type, D
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- neuron differentiation [ISS]
- peptidyl-tyrosine dephosphorylation [TAS]
- phosphate-containing compound metabolic process [NAS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Leukocyte common antigen-related receptor protein tyrosine phosphatases--comprising LAR, PTP?, and PTP?--are synaptic adhesion molecules that organize synapse development. Here, we identify glypican 4 (GPC-4) as a ligand for PTP?. GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTP?. PTP? bound only to proteolytically cleaved GPC-4 and formed additional complex with leucine-rich repeat transmembrane ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 10, 2015; 112(6);1874-9 [Pubmed: 25624497]
Throughput
- Low Throughput
Curated By
- BioGRID