BAIT
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
PREY
MAPK8IP1
IB1, JIP-1, Jip1, Prkm8ip, Skip, mjip-2a, RP23-316M14.7
mitogen-activated protein kinase 8 interacting protein 1
GO Process (10)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- JUN phosphorylation [IDA]
- negative regulation of JNK cascade [ISO]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IDA]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IMP]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA, ISO]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
In Alzheimer disease (AD) and frontotemporal dementia the microtubule-associated protein Tau becomes progressively hyperphosphorylated, eventually forming aggregates. However, how Tau dysfunction is associated with functional impairment is only partly understood, especially at early stages when Tau is mislocalized but has not yet formed aggregates. Impaired axonal transport has been proposed as a potential pathomechanism, based on cellular Tau models and ... [more]
J. Biol. Chem. Jul. 31, 2009; 284(31);20909-16 [Pubmed: 19491104]
Throughput
- Low Throughput
Curated By
- BioGRID