MAPK8IP1
Gene Ontology Biological Process
- JUN phosphorylation [IDA]
- negative regulation of JNK cascade [ISO]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IDA]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IMP]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA, ISO]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
MTAP
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
In Alzheimer disease (AD) and frontotemporal dementia the microtubule-associated protein Tau becomes progressively hyperphosphorylated, eventually forming aggregates. However, how Tau dysfunction is associated with functional impairment is only partly understood, especially at early stages when Tau is mislocalized but has not yet formed aggregates. Impaired axonal transport has been proposed as a potential pathomechanism, based on cellular Tau models and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID