BAIT
CDK5
AW048668, Crk6
cyclin-dependent kinase 5
GO Process (69)
GO Function (13)
GO Component (17)
Gene Ontology Biological Process
- Schwann cell development [IMP]
- apoptotic process [IDA]
- associative learning [IMP]
- axonogenesis [IMP]
- behavioral response to cocaine [IMP]
- calcium ion import [IMP]
- cell migration [IDA, IMP]
- cell-matrix adhesion [IDA]
- central nervous system neuron development [IMP]
- cerebellar cortex development [IMP]
- cerebellar cortex formation [IMP]
- cerebellum development [IMP]
- cerebral cortex development [IMP]
- corpus callosum development [IMP]
- cortical actin cytoskeleton organization [ISO]
- dendrite morphogenesis [IMP]
- exocytosis [ISO]
- forebrain development [IMP]
- hippocampus development [IMP]
- intracellular protein transport [IMP]
- layer formation in cerebral cortex [IMP]
- motor neuron axon guidance [IMP]
- negative regulation of axon extension [IGI]
- negative regulation of cell cycle [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IMP, ISA, ISO]
- neuron migration [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- nucleocytoplasmic transport [ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein binding [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of receptor activity [IDA]
- protein autophosphorylation [ISO]
- protein localization to synapse [IMP]
- protein phosphorylation [IDA, IGI, IMP, ISO]
- receptor catabolic process [IMP]
- receptor clustering [IMP]
- regulated secretory pathway [ISO]
- regulation of cell cycle [ISO]
- regulation of cell migration [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of synaptic plasticity [ISO]
- response to cocaine [IMP]
- response to wounding [ISO]
- sensory perception of pain [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- skeletal muscle tissue development [IDA]
- synapse assembly [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- synaptic vesicle endocytosis [ISO]
- telencephalon development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [IMP]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [ISO]
- filopodium [IDA]
- growth cone [ISO]
- intracellular [IMP]
- lamellipodium [IDA]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- postsynaptic density [ISO]
Mus musculus
PREY
HIST1H1A
H1.1, H1a, H1f1, H1var3, RP23-480B19.14-001
histone cluster 1, H1a
GO Process (1)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock.
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5 (CDK5) regulates ... [more]
Elife Dec. 05, 2018; 8(); [Pubmed: 31687929]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID