BAIT
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
PREY
GNAQ
1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI
guanine nucleotide binding protein, alpha q polypeptide
GO Process (25)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- GTP catabolic process [IBA]
- action potential [IMP]
- activation of phospholipase C activity [ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- developmental pigmentation [IMP]
- embryonic digit morphogenesis [IGI]
- forebrain neuron development [IMP]
- glutamate receptor signaling pathway [IMP]
- heart development [IMP]
- maternal behavior [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein kinase activity [ISO]
- neuron remodeling [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- post-embryonic development [IMP]
- protein stabilization [ISO]
- regulation of catenin import into nucleus [ISO]
- regulation of melanocyte differentiation [IMP]
- signal transduction [IBA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNA binding proteins co-localize with small tau inclusions in tauopathy.
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in ... [more]
Acta Neuropathol Commun Dec. 01, 2017; 6(1);71 [Pubmed: 30068389]
Throughput
- High Throughput
Curated By
- BioGRID