BAIT
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
PREY
HNRNPK
Hnrpk, KBBP, NOVA
heterogeneous nuclear ribonucleoprotein K
GO Process (8)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- positive regulation of receptor-mediated endocytosis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of low-density lipoprotein particle clearance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- single-stranded DNA binding [ISO]
- RNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNA binding proteins co-localize with small tau inclusions in tauopathy.
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in ... [more]
Acta Neuropathol Commun Dec. 01, 2017; 6(1);71 [Pubmed: 30068389]
Throughput
- High Throughput
Curated By
- BioGRID