BAIT
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
PREY
PURB
2310015K15Rik, AA114818, Cager-2, D11Bwg0414e, RP23-74L9.2
purine rich element binding protein B
GO Process (7)
GO Function (13)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [NAS]
- cell differentiation [NAS]
- cell proliferation [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of translation [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- mRNA binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [ISO]
- RNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- mRNA binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA, ISO]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNA binding proteins co-localize with small tau inclusions in tauopathy.
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in ... [more]
Acta Neuropathol Commun Dec. 01, 2017; 6(1);71 [Pubmed: 30068389]
Throughput
- High Throughput
Curated By
- BioGRID