BAIT

MAPT

AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

RNA binding proteins co-localize with small tau inclusions in tauopathy.

Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B

The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in ... [more]

Acta Neuropathol Commun Dec. 01, 2017; 6(1);71 [Pubmed: 30068389]

Throughput

  • High Throughput

Curated By

  • BioGRID