BAIT
MAPT
AI413597, AW045860, Mtapt, Tau, RP23-136D4.1
microtubule-associated protein tau
GO Process (16)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
Mus musculus
PREY
PPP3CA
2900074D19Rik, CN, Caln, Calna, CnA
protein phosphatase 3, catalytic subunit, alpha isoform
GO Process (22)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcineurin-NFAT signaling cascade [IDA, IGI, ISO]
- calcium ion transport [IMP]
- calcium-mediated signaling [IGI]
- cardiac muscle hypertrophy in response to stress [IGI]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [ISO]
- dephosphorylation [IDA]
- multicellular organismal response to stress [IDA]
- negative regulation of chromatin binding [IMP]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of insulin secretion [ISO]
- positive regulation of NFAT protein import into nucleus [IDA, IMP, ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- protein dephosphorylation [IMP, ISO]
- protein import into nucleus [IDA]
- regulation of excitatory postsynaptic membrane potential [IGI]
- regulation of synaptic transmission [IMP]
- response to calcium ion [ISO]
- skeletal muscle fiber development [IMP]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNA binding proteins co-localize with small tau inclusions in tauopathy.
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in ... [more]
Acta Neuropathol Commun Dec. 01, 2017; 6(1);71 [Pubmed: 30068389]
Throughput
- High Throughput
Curated By
- BioGRID