GLRA1
Gene Ontology Biological Process
- acrosome reaction [IMP]
- action potential [IMP]
- adult walking behavior [IMP]
- anion transport [ISO]
- chloride transmembrane transport [IMP, ISO]
- chloride transport [ISO]
- ion transmembrane transport [ISO]
- ion transport [ISO]
- muscle contraction [ISO]
- negative regulation of transmission of nerve impulse [ISO]
- neuromuscular process [IMP]
- neuromuscular process controlling posture [IMP]
- neuropeptide signaling pathway [ISO]
- positive regulation of acrosome reaction [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of respiratory gaseous exchange [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IMP]
- righting reflex [IMP]
- startle response [IMP, ISO]
- synaptic transmission [IMP]
- synaptic transmission, glycinergic [IMP, ISO]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn.
Glycine receptors (GlyRs) are pentameric proteins that consist of ? (?1-?4) subunits and/or ? subunit. In the spinal cord of adult animals, the majority of inhibitory glycinergic neurotransmission is mediated by ?1 subunit-containing GlyRs. The reduced glycinergic inhibition (disinhibition) is proposed to increase the excitabilities and spontaneous activities of spinal nociceptive neurons during pathological pain. However, the molecular mechanisms by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HUWE1 GLRA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID