HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
GPHN
Gene Ontology Biological Process
- Mo-molybdopterin cofactor biosynthetic process [IMP, ISO]
- establishment of protein localization [ISO]
- establishment of synaptic specificity at neuromuscular junction [IMP]
- glycine receptor clustering [IMP]
- molybdenum incorporation into molybdenum-molybdopterin complex [IBA]
- protein homooligomerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn.
Glycine receptors (GlyRs) are pentameric proteins that consist of ? (?1-?4) subunits and/or ? subunit. In the spinal cord of adult animals, the majority of inhibitory glycinergic neurotransmission is mediated by ?1 subunit-containing GlyRs. The reduced glycinergic inhibition (disinhibition) is proposed to increase the excitabilities and spontaneous activities of spinal nociceptive neurons during pathological pain. However, the molecular mechanisms by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID