BAIT
DYRK1A
DYRK, DYRK1, HP86, MNB, MNBH, MRD7
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
GO Process (9)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- circadian rhythm [ISS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- nervous system development [TAS]
- peptidyl-threonine phosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA, ISS]
- positive regulation of protein deacetylation [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAP1B
FUTSCH, MAP5, PPP1R102
microtubule-associated protein 1B
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.
Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, inactivating mutations in just one allele are responsible for a distinct yet rare clinical syndrome, DYRK1A haploinsufficiency. Moreover, altered expression of this kinase may also ... [more]
Sci Rep Apr. 12, 2019; 9(1);6014 [Pubmed: 30979931]
Throughput
- High Throughput
Additional Notes
- hit proteins identified in IP of bait DYRK1A epitope tagged with one of 2 C-terminal tags or with an N-terminal tag but not with a second C-terminal tag
Curated By
- BioGRID