Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.

Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH

Saturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is crucial for the progression of nonalcoholic steatohepatitis (NASH). Autophagy is required for the clearance of protein aggregates or damaged mitochondria to maintain cellular metabolic homeostasis. The NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2)-KEAP1 (kelch like ECH ... [more]

Autophagy Jan. 01, 2020; 16(1);86-105 [Pubmed: 30907226]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TOMM20

Gene Ontology Biological Process

Gene Ontology Molecular Function

P-P-bond-hydrolysis-driven protein transmembrane transporter activity [IDA]protein binding [IPI]unfolded protein binding [IDA]

Gene Ontology Cellular Component

MAP1LC3B

Gene Ontology Biological Process

Gene Ontology Molecular Function

GABA receptor binding [IBA]microtubule binding [IBA]protein binding [IPI]

Gene Ontology Cellular Component

Co-localization

Publication

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.

Throughput

Curated By

P-P-bond-hydrolysis-driven protein transmembrane transporter activity [IDA]
protein binding [IPI]
unfolded protein binding [IDA]

GABA receptor binding [IBA]
microtubule binding [IBA]
protein binding [IPI]