BAIT
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GABRG2
CAE2, ECA2, GEFSP3
gamma-aminobutyric acid (GABA) A receptor, gamma 2
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking.
Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood. BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, through positive allosteric modulation of ?2 subunit containing GABA type A receptors (GABAARs). Here we define key molecular events impacting ?2 GABAAR and ... [more]
Front Cell Neurosci May. 14, 2019; 13();163 [Pubmed: 31080408]
Throughput
- Low Throughput
Additional Notes
- assayed using FRET (fluorescence resonance energy transfer) with GABRA2 (alpha2)-bound fluorophore as donor and GABRG2 (gamma2)-bound fluorophore as acceptor
Curated By
- BioGRID