BAIT
IFITM3
1-8U, DSPA2b, IP15
interferon induced transmembrane protein 3
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- immune response [TAS]
- negative regulation of viral entry into host cell [IDA]
- negative regulation of viral genome replication [IDA]
- negative regulation of viral transcription [IDA]
- response to interferon-alpha [IDA]
- response to interferon-beta [IDA]
- response to interferon-gamma [IDA]
- response to virus [IDA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XPO1
CRM1, emb, exp1
exportin 1
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID