BAIT
OAS3
p100, p100OAS, P/OKcl.4
2'-5'-oligoadenylate synthetase 3, 100kDa
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- defense response to virus [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of viral genome replication [IDA]
- nucleobase-containing compound metabolic process [TAS]
- regulation of ribonuclease activity [IDA]
- response to virus [IDA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CNP
CNP1
2',3'-cyclic nucleotide 3' phosphodiesterase
GO Process (2)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID