BAIT
VMP1
EPG3, TANGO5, TMEM49, HSPC292
vacuole membrane protein 1
GO Process (6)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITPR1
ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29
inositol 1,4,5-trisphosphate receptor, type 1
GO Process (19)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [ISS, TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- negative regulation of calcium-mediated signaling [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of insulin secretion [TAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to hypoxia [IDA]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID