BAIT

VMP1

EPG3, TANGO5, TMEM49, HSPC292

vacuole membrane protein 1

Autophagy Project

GO Process (6)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

Golgi organization [IBA]

cell junction assembly [IMP]

endoplasmic reticulum organization [IBA]

exocytosis [IBA]

regulation of autophagy [IBA, ISS]

single organismal cell-cell adhesion [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

autophagic vacuole membrane [ISS]

endoplasmic reticulum [IDA]

pre-autophagosomal structure [IBA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PDCD6IP

AIP1, ALIX, DRIP4, HP95

programmed cell death 6 interacting protein

GO Process (7)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

positive regulation of exosomal secretion [IMP]

positive regulation of extracellular vesicular exosome assembly [IMP]

regulation of extracellular vesicular exosome assembly [IMP]

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]

viral budding via host ESCRT complex [IGI]

viral life cycle [TAS]

viral process [TAS]

Gene Ontology Molecular Function

calcium-dependent protein binding [IPI]
protein binding [IPI]
protein homodimerization activity [IPI]
proteinase activated receptor binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

endoplasmic reticulum exit site [IMP]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

immunological synapse [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A

Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]

Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]

Throughput

High Throughput

Curated By

BioGRID