BAIT
SERPINE1
PAI, PAI-1, PAI1, PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (34)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [IEP]
- blood coagulation [TAS]
- cellular response to lipopolysaccharide [IMP]
- chronological cell aging [IEP]
- defense response to Gram-negative bacterium [IGI]
- extracellular matrix organization [TAS]
- fibrinolysis [TAS]
- gene expression [TAS]
- negative regulation of blood coagulation [IC]
- negative regulation of cell adhesion mediated by integrin [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fibrinolysis [IDA]
- negative regulation of plasminogen activation [IDA, IMP]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IDA]
- negative regulation of vascular wound healing [IGI]
- negative regulation of wound healing [IC]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of leukotriene production involved in inflammatory response [IMP]
- positive regulation of monocyte chemotaxis [IMP]
- positive regulation of receptor-mediated endocytosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of receptor activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90B1
ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1
heat shock protein 90kDa beta (Grp94), member 1
GO Process (13)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- actin rod assembly [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- cellular response to ATP [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [IMP, TAS]
- protein transport [NAS]
- regulation of phosphoprotein phosphatase activity [IDA]
- response to hypoxia [IDA]
- sequestering of calcium ion [NAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum [IDA, TAS]
- endoplasmic reticulum lumen [IDA, TAS]
- endoplasmic reticulum membrane [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID