BAIT
IFIT3
CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, RP11-149I23.4
interferon-induced protein with tetratricopeptide repeats 3
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PYCR1
ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
pyrroline-5-carboxylate reductase 1
GO Process (7)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- cellular response to oxidative stress [IMP]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- proline biosynthetic process [IDA]
- regulation of mitochondrial membrane potential [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID